Below is a list of Special Weapons obtained by defeating the Robot Masters in the game Mega Man 10, how Mega Man can use them to his advantage and the Robot Master/boss who is the most vulnerable to them.
Three additional weapons can be obtained by beating the Mega Man Killers.
Special Weapons
| Special Weapons | ||||
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| Name | Chill Spike | |||
| Robot Master | Chill Man | |||
| Abilities | Similar to the Ice Slasher, this weapon launches a special freezing gel which flies in a parabolic trajectory. An enemy hit by this liquid may freeze and become unable to move. | |||
| Against | Nitro Man | |||
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| Name | Commando Bomb | |||
| Robot Master | Commando Man | |||
| Abilities | After launching it, pressing up or down on the Control Pad will make it turn at a 90 degree angle. Pressing left or right will make it turn again. When it impacts a wall, ceiling, or floor, it will produce a large blast which spreads horizontally or vertically. | |||
| Against | Blade Man | |||
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| Name | Rebound Striker | |||
| Robot Master | Strike Man | |||
| Abilities | Mega Man throws a rubber ball straight forward or diagonally up or down. As it gets faster and stronger with each successive bound, it inflicts more damage to the target. It can bounce up to four times. | |||
| Against | Sheep Man | |||
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| Name | Solar Blaze | |||
| Robot Master | Solar Man | |||
| Abilities | Splits apart and launches firebombs to the left and right after a set period of time. | |||
| Against | Chill Man | |||
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| Name | Thunder Wool | |||
| Robot Master | Sheep Man | |||
| Abilities | Launches a thunder cloud that slowly rises, and a lightning bolt shoots straight down from the cloud. Can fire up to two consecutive shots. | |||
| Against | Pump Man | |||
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| Name | Triple Blade | |||
| Robot Master | Blade Man | |||
| Abilities | Fires three blades that move in three different directions, attacking multiple enemies at the same time. | |||
| Against | Strike Man | |||
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| Name | Water Shield | |||
| Robot Master | Pump Man | |||
| Abilities | When equipped with this weapon, a rotating shield of water surrounds the user. Pressing the attack button once more hurls high-speed drops of water that spiral outward, deactivating it. | |||
| Against | Solar Man, Wily Machine No. 10 | |||
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| Name | Wheel Cutter | |||
| Robot Master | Nitro Man | |||
| Abilities | Launches up to three sharp spinning wheels from a distance. | |||
| Against | Commando Man | |||
Killer Weapons
| Mega Man Killer Weapons | ||||
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| Name | Ballade Cracker | |||
| Robot Master | Ballade | |||
| Abilities | Can be shot in multiple directions, exploding on impact. | |||
| Against | Enker | |||
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| Name | Mirror Buster | |||
| Robot Master | Enker | |||
| Abilities | All the ugly n wor | |||
| Against | Punk | |||
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| Name | Screw Crusher | |||
| Robot Master | Punk | |||
| Abilities | Throws a powerful saw that moves up for a while and then loops down. | |||
| Against | Ballade, Wily Machine No. 10 | |||