A common athropod in North America, many cockroaches in Raccoon City were infected with the T-virus. The infected cockroaches show little-to-no change in their body or intelligence when infected with the virus.
- In the film Biohazard 4D-Executer, a cockroach was infected with the "t-Cameron virus," which allowed Dr. Cameron to take control of it. She controlled the creature up until she saw a rat, in which she passed the virus on. An infected cockroach also grew to a humanoid size and had large arms that had sharps talons and could impale victims within range, codenamed Reaper.