Annette Birkin is a character from Resident Evil 2 and Resident Evil: The Darkside Chronicles.
Annette (voiced by Jennifer Dale) is a scientist for the Umbrella Corporation, as well as the wife of William and Sherry's mother.
She plays an important role in the game, but her attitude toward Leon/Ada and Claire/Sherry differs. She cooperates with Claire Redfield when her daughter is in danger, and the "Claire A" scenario, provides her with documents that help Claire to create a G-Virus vaccine to cure Sherry. In contrast, she is openly hostile toward Leon and Ada Wong; during the course of the game, Annette shoots Leon (and Ada, too, in the Leon A scenario) - although she fails to kill either.
Demise
Like her attitudes toward the heroes of the game, her death also differs: if the player follows the Claire A/Leon B path, Annette is killed by her mutated husband. If the player follows the Leon A/Claire B path, Annette is fatally wounded by falling debris.
Original Fate
Annette's original fate, which early concept art has shown, shows her transforming into a mutation like her husband.